Pluripotent stem cells (PSCs) are a promising tool for regenerative medicine, given their self-renewal potential and ability to differentiate into multiple cell lineages. However, the differentiation capacity of PSCs frequently decreases during in vitro expansion, hindering research efforts.
In this regard, BU has contributed to a recent work showcasing miR-203, a single microRNA which improves PSCs differentiation by promoting DNA demethylation after a short exposure . The results showcased in the publication suggest that miR-203 is a versatile method to reset the epigenetic memory in PSCs and improve their effectiveness in regenerative medicine.
The full article has been published at The EMBO Journal and is available here.