The Therapeutic Cancer Cell Atlas (TCCA)
We are developing the Therapeutic Cancer Cell Atlas (TCCA), a pan-cancer single-cell resource integrating ~1.8 million transcriptomes from +500 patients and +180 cancer cell lines across +30 tumor types. By combining single-cell transcriptomics with computational approaches to infer genomic alterations and predict drug response, TCCA maps therapeutic heterogeneity at subclonal resolution and identifies conserved and tumor-specific drug vulnerabilities. This project provides a framework to understand how cancer cell states and the tumor microenvironment shape therapeutic response, with the goal of improving treatment prioritization, identifying opportunities for drug repurposing, and informing combination therapies in precision oncology.
