2026

Imaging MRI biomarkers for diagnosing brain radionecrosis: focus on incomplete ring enhancement sign

Ortiz de Mendivil A, Santana-Suarez E, Perez-Beteta J, Ciervide R, Diamantopoulos J, Martin P, Sepulveda JM, Hernandez-Lain A, Tramblin C, Garcia-Duque S, Ocaña-Tienda B, Rubio C, Koren L. Neuroradiology. 2026 Jul 25. doi: 10.1007/s00234-026-04096-4. Epub ahead of print. PMID: 42501086.

A clinical decision-support framework to differentiate radiation necrosis from tumor progression in brain metastases

Beatriz Ocaña-Tienda, Zhao Hui Chen Zhou, Ana Ramos, Ana Ortiz de Mendivil, Fatima Nagib-Raya, Beatriz Asenjo, Alberto Bastero, Carlos Tramblin, Estanislao Arana, Víctor M Pérez-García. Neuro-Oncology Advances, 2026;, vdag185. DOI: 10.1093/noajnl/vdag185.

Intercellular adhesion molecule 1 links glioblastoma biology to a scalable prognostic model integrating clinical, imaging, and molecular features

Shreya Gandhi, Beatriz Ocaña-Tienda, Manuel M Bettencourt, Olivia S Singh, Kaviya Devaraja, Emily R Irish, David Molina-García, Shirin Karimi, Yasin Mamatjan, Julio Sosa, Ian McIntyre, Andrew F Gao, Julián Pérez-Beteta, Ana Ramos-González, Aurelio Hernández-Laín, Beatriz Asenjo, María Pino Flores-Rial, Pilar Sánchez-Gómez, Kenneth D Aldape, Carlos Santos, Katharine J Drummond, Ian F Parney, Carlos Velasquez, Alireza Mansouri, Victor M Pérez-García, Gelareh Zadeh, Sheila Mansouri. Neuro-Oncology Advances. 2026;, vdag182. DOI: 10.1093/noajnl/vdag182.

A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance.

Liaki V, Barrambana S, Kostopoulou M, Lechuga CG, Zamorano-Dominguez E, Acosta-Gallego D, Morales-Cacho L, Álvarez-Díaz R, Sun P, Rosas-Perez B, Barrero R, Jiménez-Parrado S, López-García A, San Roman M, López-Gil JC, Drosten M, Sainz B Jr, Musteanu M, Caleiras E, Dusetti N, Poli V, Sánchez-Bueno F, Guerra C, Barbacid M. Proc Natl Acad Sci U S A. 2026 Jun 9;123(23):e2610708123. doi: 10.1073/pnas.2610708123. Epub 2026 Jun 1. PMID: 42224594.

MIF-Induced CD74+ Microglia and Macrophages Promote Progression of Brain Metastasis and are Clinically Relevant Across Central Nervous System Disorders

Alvaro-Espinosa L, Marquez-Galera A, Priego N, García-Calvo V, Perea-García M, Hernandez-Oliver C, Retana D, Sanchez O, de Pablos-Aragoneses A, García-Gómez P, Graña-Castro O, Lapuente-Santana Ó, Serrano-Ron L, Al-Shahrour F, Cayuela López A, Peset I, Megías D, Ola M, Varešlija D, Young LS, Martí-Mateos Y, Enríquez JA, Hernández-Encinas E, Blanco-Aparicio C, Soengas MS, Bernhagen J, Antón-Fernández A, Ávila J, Marchena MA, Torres M, de Castro F, Márquez-Ropero M, Sierra A, Lopez-Atalaya JP, Group R, Valiente M, Baena Galán P, Sobrino C, Almenara I, Alba-Olano D, Ortega-Sabater C, Artiga MJ, Ortega-Paino E, González Piñeiro A, Fiaño Valverde C, de la Lama Zaragoza A, Londoño Quiroz A, Delgado López PD, Pascual-Llorente M, Díaz-Piqueras Á, Arriaga Aragón ÁA, Nam-Cha S, Barrena-López C, Plans Ahicart G, Escolano Otín B, Gil Aldea I, Delgado-Fernández J, Sepúlveda-Sánchez JM, Perez-Nuñez A, Hernández-Laín A, Toldos González O, Gargini R, Alcivar D, Fernández Alén JA, Blasco García de Andoain G, Cepeda Chafla S, Martínez Zamorano E, Mollejo Villanueva M, Opazo Rodríguez MS, Rodriguez de Lope Llorca Á, Arbaiza Martínez M, Múzquiz Rueda GM, Benavente S, Martínez-Ricarte F, Ramón Y Cajal S, Sesé Faustino M, Fernández Cabré L, Hernández-Losa J, Martínez-Saez E, Calero Félix L, Vargas-Osorio K. Cancer Res. 2026 Mar 24:10.1158/0008-5472.CAN-25-4018. doi: 10.1158/0008-5472.CAN-25-4018. Epub ahead of print. PMID: 41874311.

Rank signaling drives basal cell-lineage infidelity leading to mammary tumorigenesis