2020
- CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma.
Salvador-Barbero, B., Álvarez-Fernández, M., Zapatero-Solana, E., El Bakkali, A., Menéndez, M. del C., López-Casas, P.P., Di Domenico, T., Xie, T., VanArsdale, T., Shields, D.J., Hidalgom M, Malumbres, M.
Cancer Cell. 2020 Feb. doi: 10.1016/j.ccell.2020.01.007. PMID: 32109375 [Article] - The mTOR Pathway Is Necessary for Survival of Mice With Short Telomeres.
Iole Ferrara-Romeo, Paula Martinez, Sarita Saraswati, Kurt Whittemore, Osvaldo Graña-Castro, Lydia Thelma Poluha, Rosa Serrano, Elena Hernandez-Encinas, Carmen Blanco-Aparicio, Juana Maria Flores, Maria A Blasco.
Nature Communications. 2020 Mar 3; 11 (1), 1168. doi: 10.1038/s41467-020-14962-1. PubMed PMID: 32127537 [Article] - Pan-cancer analysis of whole genomes.
The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium
Nature 578, pages82–93(2020). doi: 10.1038/s41586-020-1969-6. PubMed PMID: 32025007 [Article]
2019
- MEK inhibition enhances the response to tyrosine kinase inhibitors in acute myeloid leukemia.
Morales ML, Arenas A, Ortiz-Ruiz A, Leivas A, Rapado I, Rodríguez-García A, Castro N, Zagorac I, Quintela-Fandino M, Gómez-López G, Gallardo M, Ayala R, Linares M, Martínez-López J.
Sci Rep. 2019 Dec 9;9(1):18630. doi: 10.1038/s41598-019-54901-9. PubMed PMID: 31819100 [Article] - Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation.
Helbling PM, Piñeiro-Yáñez E, Gerosa R, Boettcher S, Al-Shahrour F, Manz MG, Nombela-Arrieta C.
Cell Rep. 2019 Dec 3;29(10):3313-3330.e4. doi: 10.1016/j.celrep.2019.11.004. PubMed PMID: 31801092 [Article] - The correlation between immune subtypes and consensus molecular subtypes in colorectal cancer identifies novel tumour microenvironment profiles, with prognostic and therapeutic implications.
B. Soldevilla, C. Carretero-Puche, G. Gómez-López, F. Al-Shahrour, MC. Riesco, B. Gil-Calderon, L. Alvarez-Vallina, P. Espinosa-Olarte, G. Gómez-Esteves, B. Rubio-Cuesta, J. Sarmentero, A. La Salvia, R. Garcia-Carbonero.
Eur J Cancer. 2019 Oct 31;123:118-129. doi: 10.1016/j.ejca.2019.09.008. PubMed PMID: 31678770 [Article] - The use of PanDrugs to prioritize anticancer drug treatments in a case of T-ALL based on individual genomic data.
Fernández-Navarro P, López-Nieva P, Piñeiro-Yañez E, Carreño-Tarragona G, Martinez-López J, Sánchez Pérez R, Aroca Á, Al-Shahrour F, Cobos-Fernández MÁ, Fernández-Piqueras J.
BMC Cancer. 2019 Oct 26;19(1):1005. doi: 10.1186/s12885-019-6209-9. PubMed PMID: 31655559 [Article] - Role of bulge epidermal stem cells and TSLP signaling in psoriasis.
Nuria Gago‐Lopez, Liliana F Mellor, Diego Megías, Guillermo Martín‐Serrano, Ander Izeta, Francisco Jimenez, Erwin F Wagner.
EMBO Mol Med. 2019, 26 Sep, e10697; https://doi.org/10.15252/emmm.201910697. PubMed PMID: 31556482 [Article] - In silico drug prescription for targeting cancer patient heterogeneity and prediction of clinical outcome.
Elena Piñeiro-Yáñez, María José Jiménez-Santos, Gonzalo Gómez-López, Fátima Al-Shahrour.
Cancers. 2019, 11(9), 1361; https://doi.org/10.3390/cancers11091361. PubMed PMID: 31540260 [Article] - Oncogenic Rag GTPase signalling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR.
Ortega-Molina A, Deleyto-Seldas N, Carreras J, Sanz A, Lebrero-Fernández C, Menéndez C, Vandenberg A, Fernández-Ruiz B, Marín-Arraiza L, Calle Arregui C, Plata-Gómez A, Caleiras E, de Martino A, Martínez-Martín N, Troulé K, Piñeiro-Yañez E, Nakamura N, Araf S, Victoria G, Okosun J, Fitzgibbon, Efeyan A.
Nat. Metab. 2019, Aug, doi: 10.1038/s42255-019-0098-8. PubMed PMID: 31579886 [Article] - Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo.
Peña-Jimenez D, Fontenete S, Megias D, Fustero-Torre C, Graña-Castro O, Castellana D, Loewe R, Perez-Moreno M.
EMBO J. 2019 Sep 2:e101688. doi: 10.15252/embj.2019101688. PubMed PMID: 31475747 [Article] - TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2.
Marión RM, Montero JJ, López de Silanes I, Graña-Castro O, Martínez P, Schoeftner S, Palacios-Fábrega JA, Blasco MA.
Elife. 2019 Aug 20; 8 (pii: e44656). doi: 10.7554/eLife.44656. PubMed PMID: 31426913 [Article] - Hsa-miR-139-5p is a prognostic thyroid cancer marker involved in HNRNPF-mediated alternative splicing.
Montero-Conde C, Graña-Castro O, Martín-Serrano G, Martínez-Montes ÁM, Zarzuela E, Muñoz J, Torres-Perez R, Pita G, Cordero-Barreal A, Leandro-García LJ, Letón R, de Silanes IL, Guadalix S, Pérez-Barrios A, Hawkins F, Guerrero-Álvarez A, Álvarez-Escolá C, Regojo-Zapata R, Calsina B, Remacha L, Roldán-Romero JM, Santos M, Lanillos J, Jordá M, Riesco-Eizaguirre G, Zafon C, González-Neira A, Blasco MA, Al-Shahrour F, Rodríguez-Antona C, Cascón A, Robledo M.
Int J Cancer. 2019 Aug 12; doi: 10.1002/ijc.32622. PubMed PMID: 31403184 [Article] - Integrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/mTOR axis in metastatic pheochromocytoma/paraganglioma.
Calsina B, Castro-Vega LJ, Torres-Pérez R, Inglada-Pérez L, Currás-Freixes M, Roldán-Romero JM, Mancikova V, Letón R, Remacha L, Santos M, Burnichon N, Lussey-Lepoutre C, Rapizzi E, Graña O, Álvarez-Escolá C, A de Cubas A, Lanillos J, Cordero-Barreal A, Martínez-Montes AM, Bellucci A, Amar L, Luiz Fernandes-Rosa F, Calatayud M, Aller J, Lamas C, Sastre-Marcos J, Canu L, Korpershoek E, Timmers HJ, Lenders JWM, Beuschlein F, Fassnacht-Capeller M, Eisenhofer G, Mannelli M, Al-Shahrour F, Favier J, Rodríguez-Antona C, Cascón A, Montero-Conde C, Gimenez-Roqueplo AP, Robledo M.
Theranostics. 2019; 9(17):4946-4958. doi:10.7150/thno.35458. PubMed PMID: 31410193 [Article] - Specific contributions of Cohesin-SA1 and Cohesin-SA2 to TADs and Polycomb domains in embryonic stem cells.
Cuadrado A, Giménez-Llorente D, Kojic A, Rodríguez-Corsino M, Cuartero Y, Martín-Serrano G, Gómez-López G, Marti-Renom MA, Losada A.
Cell Reports. 2019 Jun 18;27(12):3500-3510.e4. doi: 10.1016/j.celrep.2019.05.078. PubMed PMID: 31216471 [Article] - vulcanSpot: a tool to prioritize therapeutic vulnerabilities in cancer.
Perales-Patón J, Di Domenico T, Fustero-Torre C, Piñeiro-Yáñez E, Carretero-Puche C, Tejero H, Valencia A, Gómez-López G, Al-Shahrour F.
Bioinformatics. 2019 Jun 7. pii: btz465. doi: 10.1093/bioinformatics/btz465. PubMed PMID: 31173067 [Article] - Blasco MT, Navas C, Martín-Serrano G, Graña-Castro O, Lechuga CG, Martín-Díaz L, Djurec M, Li J, Morales-Cacho L, Esteban-Burgos L, Perales-Patón J, Bousquet-Mur E, Castellano E, Jacob HKC, Cabras L, Musteanu M, Drosten M, Ortega S, Mulero F, Sainz B Jr, Dusetti N, Iovanna J, Sánchez-Bueno F, Hidalgo M, Khiabanian H, Rabadán R, Al-Shahrour F, Guerra C, Barbacid M.
Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF.
Cancer Cell. 2019 Apr 8. pii: S1535-6108(19)30111-4. PubMed PMID: 30975481 [Article] - Urdinguio RG, Lopez V, Bayón GF, Diaz de la Guardia R, Sierra MI, García-Toraño E, Perez RF, García MG, Carella A, Pruneda PC, Prieto C, Dmitrijeva M, Santamarina P, Belmonte T, Mangas C, Diaconu E, Ferrero C, Tejedor JR, Fernandez-Morera JL, Bravo C, Bueno C, Sanjuan-Pla A, Rodriguez RM, Suarez-Alvarez B, López-Larrea C, Bernal T, Colado E, Balbín M, García-Suarez O, Chiara MD, Sáenz-de-Santa-María I, Rodríguez F, Pando-Sandoval A, Rodrigo L, Santos L, Salas A, Vallejo-Díaz J, C Carrera A, Rico D, Hernández-López I, Vayá A, Ricart JM, Seto E, Sima-Teruel N, Vaquero A, Valledor L, Cañal MJ, Pisano D, Graña-Castro O, Thomas T, Voss AK, Menéndez P, Villar-Garea A, Deutzmann R, Fernandez AF, Fraga MF.
Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment.
Nucleic Acids Res.. 2019 Mar 29. PubMed PMID: 30923829 [Article] - López-Nieva P, Fernández-Navarro P, Graña-Castro O, Andrés-León E, Santos J, Villa-Morales M, Cobos-Fernández MÁ, González-Sánchez L, Malumbres M, Salazar-Roa M, Fernández-Piqueras J.
Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma.
Sci Rep. 2019 March 26;9:5179. PubMed PMID: 30914738 [Article] - Vázquez-Domínguez I, González-Sánchez L, López-Nieva P, Fernández-Navarro P, Villa-Morales M, Cobos-Fernández MÁ, Sastre I, F Fraga M, F Fernández A, Malumbres M, Salazar-Roa M, Graña-Castro O, Santos J, Llamas P, López-Lorenzo JL, Fernández-Piqueras J.
Clonal dynamics monitoring during clinical evolution in chronic lymphocytic leukaemia.
Oncogene . 2019 Feb 11; doi:10.1038/s41388-019-0746-1. PubMed PMID: 30742097 [Article] - González-Rincón, J., Gómez, S., Martinez, N., Troulé, K., Perales-Patón, J., Derdak, S., Beltrán, S., Fernández-Cuevas, B., Pérez-Sanz, N., Nova-Gurumeta, S., Gut, I., Al-Shahrour, F., Piris, M.A., García-Marco, J.A., Sánchez-Beato, M.
Clonal dynamics monitoring during clinical evolution in chronic lymphocytic leukaemia.
Sci Rep. 2019 Jan 30;9(1):975. PubMed PMID: 30700761 [Article] - Panagiotis Karras, Erica Riveiro-Falkenbach, Estela Cañón, Cristina Tejedo, Tonantzin G. Calvo, Raúl Martínez-Herranz, Direna Alonso-Curbelo, Metehan Cifdaloz, Eva Perez-Guijarro, Gonzalo Gómez-López, Pilar Ximenez-Embun, Javier Muñoz, Diego Megias, David Olmeda, Jorge Moscat, Pablo L. Ortiz-Romero, Jose L. Rodríguez-Peralto, María S. Soengas.
p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.
Cancer Cell. 2019. Volume 35, 2019-01, 1 – 18. PubMed PMID: 30581152 [Article] - Frankish A, Diekhans M, Ferreira AM, Johnson R, Jungreis I, Loveland J, Mudge JM, Sisu C, Wright J, Armstrong J, Barnes I, Berry A, Bignell A, Carbonell Sala S, Chrast J, Cunningham F, Di Domenico T, Donaldson S, Fiddes IT, García Girón C, Gonzalez JM, Grego T, Hardy M, Hourlier T, Hunt T, Izuogu OG, Lagarde J, Martin FJ, Martínez L, Mohanan S, Muir P, Navarro FCP, Parker A, Pei B, Pozo F, Ruffier M, Schmitt BM, Stapleton E, Suner MM, Sycheva I, Uszczynska-Ratajczak B, Xu J, Yates A, Zerbino D, Zhang Y, Aken B, Choudhary JS, Gerstein M, Guigó R, Hubbard TJP, Kellis M, Paten B, Reymond A, Tress ML, Flicek P.
GENCODE reference annotation for the human and mouse genomes.
Nucleic Acids Res. 2019 Jan 8;47(D1):D766-D773. PubMed PMID: 30357393 [Article] - Forsthuber A, Lipp K, Andersen L, Ebersberger S, Graña-Castro O, Ellmeier W, Petzelbauer P, Lichtenberger BM, Loewe R.
CXCL5 as regulator of neutrophil function in cutaneous melanoma.
J Invest Dermatol.. 2019 Jan;139(1):186-194. PubMed PMID: 30009831 . [Article]
2018
- Paumard-Hernández B, Calvete O, Inglada Pérez L, Tejero H, Al-Shahrour F, Pita G, Barroso A, Carlos Triviño J, Urioste M, Valverde C, González Billalabeitia E, Quiroga V, Francisco Rodríguez Moreno J, Fernández Aramburo A, López C, Maroto P, Sastre J, José Juan Fita M, Duran I, Lorenzo-Lorenzo I, Iranzo P, García Del Muro X, Ros S, Zambrana F, María Autran A, Benítez J.
Whole exome sequencing identifies PLEC, EXO5 and DNAH7 as novel susceptibility genes in testicular cancer.
Int J Cancer 2018 Oct 15;143(8):1954-1962. PubMed PMID: 29761480 [Article] - Abascal F, Juan D, Jungreis I, Martinez L, Rigau M, Rodriguez JM, Vazquez J, Tress ML.
Loose ends: almost one in five human genes still have unresolved coding status.
Nucleic Acids Res. 2018 Aug 21;46(14):7070-7084. PubMed PMID: 29982784 [Article] - Zagorac I, Fernandez S, Penning R, Post H, Bueno MJ, Mouron S, Manso L, Morente MM, Alonso S, Serra V, Muñoz J, Gómez-López G, Jimenez-Renard V, Al-Shahrour F, Piñeiro-Yañez E, Pujana MA, Mateo F, Villanueva A, Montoya-Suarez JL, Apala JV, Moreno-Torres A, Colomer R, Dopazo A, Heck A.J.R, Maarten Altelaar AF, Quintela-Fandino M.
In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer.
Nat Commun.. 2018; 9(1):3501. PubMed PMID: 30158526. [Article] - Valiño-Rivas L, Cuarental L, Grana O, Bucala R, Leng L, Sanz A, Gomez G, Ortiz A, Sanchez-Niño MD.
TWEAK increases CD74 expression and sensitizes to DDT proinflammatory actions in tubular cells.
PLoS One. 2018 Jun 20. PubMed PMID: 29924850 . [Article] - Priego N, Zhu L, Monteiro C, Mulders M, Wasilewski D, Bindeman W, Doglio L, Martínez L, Martínez-Saez E, Cajal SRY, Megías D, Hernández-Encinas E, Blanco-Aparicio C, Martínez L, Zarzuela E, Muñoz J, Fustero-Torre C, Piñeiro-Yáñez E, Hernández-Laín A, Bertero L, Poli V, Sanchez-Martinez M, Menendez JA, Soffietti R, Bosch-Barrera J, Valiente M.
STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis.
Nat Med. 2018 Jun 11. PubMed PMID: 29892069. [Article] - Garcia-Carpizo V, Ruiz-Llorente S, Sarmentero J, Graña-Castro O, Pisano DG, Barrero MJ.
CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation.
Epigenetics Chromatin. 2018 Jun 8;11(1):30. PubMed PMID: 29884215. [Article] - Elena Piñeiro-Yáñez, Miguel Reboiro-Jato, Gonzalo Gómez-López, Javier Perales-Patón, Kevin Troulé, José Manuel Rodríguez, Héctor Tejero, Takeshi Shimamura, Pedro Pablo López-Casas, Julián Carretero, Alfonso Valencia, Manuel Hidalgo, Daniel Glez-Peña and Fátima Al-Shahrour.
PanDrugs: a novel method to prioritize anticancer drug treatments according to individual genomic data.
Genome Med. 2018; 10:41. PubMed PMID: 29848362. [Article] - Aleksandar Kojic, Ana Cuadrado, Magali De Koninck, Daniel Giménez-Llorente, Miriam Rodríguez-Corsino, Gonzalo Gómez-López, François Le Dily, Marc A. Marti-Renom, Ana Losada.
Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization.
Nat Struct Mol Biol. 2018. DOI: 10.1038/s41594-018-0070-4. PubMed PMID: 29867216. - López-Nieva P, Fernández-Navarro P, Vaquero-Lorenzo C, Villa-Morales M, Graña-Castro O, Cobos-Fernández MÁ, López-Lorenzo JL, Llamas P, González-Sanchez L, Sastre I, Pollan M, Malumbres M, Santos J, Fernández-Piqueras J.
RNA-Seq reveals the existence of a CDKN1C-E2F1-TP53 axis that is altered in human T-cell lymphoblastic lymphomas.
BMC Cancer. 2018; 18(1):430. PubMed PMID: 29661169. PMCID: PMC5902834. - Oldrini B, Curiel-García Á, Marques C, Matia V, Uluçkan Ö, Graña-Castro O, Torres-Ruiz R, Rodriguez-Perales S, Huse JT, Squatrito M.
Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling.
Nat Commun. 2018; 9(1):1466. PubMed PMID: 29654229. PMCID: PMC5899147. - Djurec M, Graña O, Lee A, Troulé K, Espinet E, Cabras L, Navas C, Blasco MT, Martín-Díaz L, Burdiel M, Li J, Liu Z, Vallespinós M, Sanchez-Bueno F, Sprick MR, Trumpp A, Sainz B Jr., Al-Shahrour F, Rabadan R, Guerra C, Barbacid M.
Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors.
Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1147-E1156. doi: 10.1073/pnas.1717802115. PubMed PMID: 29351990. - Juan Manuel Povedano, Paula Martinez, Rosa Serrano, Águeda Tejera, Gonzalo Gómez-López, Maria Bobadilla, Juana Maria Flores, Fátima Bosch, Maria A Blasco.
Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres.
Elife. 2018 Jan 30;7. pii: e31299. doi: 10.7554/eLife.31299. PubMed PMID: 29378675. - Lynch CJ, Bernad R, Calvo I, Nóbrega-Pereira S, Ruiz S, Ibarz N, Martinez-Val A, Graña-Castro O, Gómez-López G, Andrés-León E, Espinosa Angarica V, Del Sol A, Ortega S, Fernandez-Capetillo O, Rojo E, Munoz J, Serrano M.
The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity.
Cell Rep. 2018 Jan 9;22(2):396-410. doi: 10.1016/j.celrep.2017.12.062. PubMed PMID: 29320736. - O. Graña; M. Rubio-Camarillo; F. Fdez-Riverola; D.G. Pisano; D. Glez-Peña.
Nextpresso: next generation sequencing expression analysis pipeline.
Current Bioinformatics 2018. Volume 13 (6):583 – 591. DOI: 10.2174/1574893612666170810153850. [Article]
2017
- Apellániz-Ruiz M, Tejero H, Inglada-Pérez L, Sánchez-Barroso L, Gutiérrez-Gutiérrez G, Calvo I, Castelo B, Redondo A, García-Donás J, Romero-Laorden N, Sereno M, Merino M, Currás-Freixes M, Montero-Conde C, Mancikova V, Åvall-Lundqvist E, Green H, Al-Shahrour F, Cascón A, Robledo M, Rodríguez-Antona C.
Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy.
Clin Cancer Res. 2017 Mar 1;23(5):1227-1235. doi: 10.1158/1078-0432.CCR-16-0694. PubMed PMID: 27582484.
- Vu LP, Prieto C, Amin EM, Chhangawala S, Krivtsov A, Calvo-Vidal MN, Chou T, Chow A, Minuesa G, Park SM, Barlowe TS, Taggart J, Tivnan P, Deering RP, Chu LP, Kwon JA, Meydan C, Perales-Paton J, Arshi A, Gönen M, Famulare C, Patel M, Paietta E, Tallman MS, Lu Y, Glass J, Garret-Bakelman FE, Melnick A, Levine R, Al-Shahrour F, Järås M, Hacohen N, Hwang A, Garippa R, Lengner CJ, Armstrong SA, Cerchietti L, Cowley GS, Root D, Doench J, Leslie C, Ebert BL, Kharas MG.
Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells.
Nat Genet. 2017 Jun;49(6):866-875. doi: 10.1038/ng.3854. PubMed PMID: 28436985
- Romero-Laorden N, Piñeiro-Yañez E, Gutierrez-Pecharroman A, Pacheco MI, Calvo E, Al-Shahrour F, Castro E, Olmos D. Somatic BRCA2 bi-allelic loss in the primary prostate cancer was associated to objective response to PARPi in a sporadic CRPC.
Ann Oncol. 2017 May 1;28(5):1158-1159. doi: 10.1093/annonc/mdx067. PubMed PMID: 28453706.
- Currás-Freixes M, Piñeiro-Yañez E, Montero-Conde C, Apellániz-Ruiz M, Calsina B, Mancikova V, Remacha L, Richter S, Ercolino T, Rogowski-Lehmann N, Deutschbein T, Calatayud M, Guadalix S, Álvarez-Escolá C, Lamas C, Aller J, Sastre-Marcos J, Lázaro C, Galofré JC, Patiño-García A, Meoro-Avilés A, Balmaña-Gelpi J, De Miguel-Novoa P, Balbín M, Matías-Guiu X, Letón R, Inglada-Pérez L, Torres-Pérez R, Roldán-Romero JM, Rodríguez-Antona C, Fliedner SMJ, Opocher G, Pacak K, Korpershoek E, de Krijger RR, Vroonen L, Mannelli M, Fassnacht M, Beuschlein F, Eisenhofer G, Cascón A, Al-Shahrour F, Robledo M.
PheoSeq: A Targeted Next-Generation Sequencing Assay for Pheochromocytoma and Paraganglioma Diagnostics.
J Mol Diagn. 2017 Jul;19(4):575-588. doi: 10.1016/j.jmoldx.2017.04.009. PubMed PMID: 28552549.
- Rajeshkumar NV, Yabuuchi S, Pai SG, De Oliveira E, Kamphorst JJ, Rabinowitz JD, Tejero H, Al-Shahrour F, Hidalgo M, Maitra A, Dang CV.
Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin.
Clin Cancer Res. 2017 Sep 15;23(18):5639-5647. doi: 10.1158/1078-0432.CCR-17-1115. PubMed PMID: 28611197.
- Sánchez-Valle J, Tejero H, Ibáñez K, Portero JL, Krallinger M, Al-Shahrour F, Tabarés-Seisdedos R, Baudot A, Valencia A.
A molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer’s Disease, Glioblastoma and Lung cancer.
Sci Rep. 2017 Jun 30;7(1):4474. doi: 10.1038/s41598-017-04400-6. PubMed PMID: 28667284.
- Perales-Patón J, Piñeiro-Yañez E, Tejero H, López-Casas PP, Hidalgo M, Gómez-López G, Al-Shahrour F.
Pancreas Cancer Precision Treatment Using Avatar Mice from a Bioinformatics Perspective.
Public Health Genomics. 2017;20(2):81-91. doi: 10.1159/000479812. PubMed PMID: 28858862.
- Gómez-López G, Dopazo J, Cigudosa JC, Valencia A, Al-Shahrour F.
Precision medicine needs pioneering clinical bioinformaticians.
Brief Bioinform. 2017 Oct 25. doi: 10.1093/bib/bbx144. PubMed PMID: 29077790.
- Cifdaloz M, Osterloh L, Graña O, Riveiro-Falkenbach E, Ximénez-Embún P, Muñoz J, Tejedo C, Calvo TG, Karras P, Olmeda D, Miñana B, Gómez-López G, Cañon E, Eyras E, Guo H, Kappes F, Ortiz-Romero PL, Rodríguez-Peralto JL, Megías D, Valcárcel J, Soengas MS.
Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.
Nat Commun. 2017 Dec 21;8(1):2249. doi: 10.1038/s41467-017-02353-y. PubMed PMID: 29269732.
- Nieto P, Ambrogio C, Esteban-Burgos L, Gómez-López G, Blasco MT, Yao Z, Marais R, Rosen N, Chiarle R, Pisano DG, Barbacid M, Santamaría D.
A Braf kinase-inactive mutant induces lung adenocarcinoma.
Nature. 2017 Aug 10;548(7666):239-243. doi: 10.1038/nature23297. PubMed PMID: 28783725.
- Rio-Machin A, Gómez-López G, Muñoz J, Garcia-Martinez F, Maiques-Diaz A, Alvarez S, Salgado RN, Shrestha M, Torres-Ruiz R, Haferlach C, Larráyoz MJ, Calasanz MJ, Fitzgibbon J, Cigudosa JC.
The molecular pathogenesis of the NUP98-HOXA9 fusion protein in acute myeloid leukemia.
Leukemia. 2017 Sep;31(9):2000-2005. doi: 10.1038/leu.2017.194. PubMed PMID: 28630438.
- Gimenez-Xavier P, Pros E, Bonastre E, Moran S, Aza A, Graña O, Gomez-Lopez G, Derdak S, Dabad M, Esteve-Codina A, Hernandez Mora JR, Salinas-Chaparro D, Esteller M, Pisano D, Sanchez-Cespedes M.
Genomic and Molecular Screenings Identify Different Mechanisms for Acquired Resistance to MET Inhibitors in Lung Cancer Cells.
Mol Cancer Ther. 2017 Jul;16(7):1366-1376. doi: 10.1158/1535-7163.MCT-17-0104. PubMed PMID: 28396363.
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Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies B2M Inactivation Impairing Immunorecognition.
Clin Cancer Res. 2017 Jun 15;23(12):3203-3213. doi: 10.1158/1078-0432.CCR-16-1946. PubMed PMID: 28302866.
- Andrés-León E, Gómez-López G, Pisano DG.
Prediction of miRNA-mRNA Interactions Using miRGate.
Methods Mol Biol. 2017;1580:225-237. doi: 10.1007/978-1-4939-6866-4_15. PubMed PMID: 28439836.
- Rubio-Camarillo M, López-Fernández H, Gómez-López G, Carro Á, Fernández JM, Torre CF, Fdez-Riverola F, Glez-Peña D.
RUbioSeq+: A multiplatform application that executes parallelized pipelines to analyse next-generation sequencing data.
Comput Methods Programs Biomed. 2017 Jan;138:73-81. doi: 10.1016/j.cmpb.2016.10.008. PubMed PMID: 27886717.
- Graña O, López-Fernández H, Fdez-Riverola F, González Pisano D, Glez-Peña D.
Bicycle: a bioinformatics pipeline to analyze bisulfite sequencing data.
Bioinformatics. 2017 Dec 1. doi: 10.1093/bioinformatics/btx778. PubMed PMID: 29211825.
- Simón-Carrasco L, Graña O, Salmón M, Jacob HKC, Gutierrez A, Jiménez G, Drosten M, Barbacid M.
Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma.
Genes Dev. 2017 Jul 15;31(14):1456-1468. doi: 10.1101/gad.300244.117. PubMed PMID: 28827401
- Olmeda D, Cerezo-Wallis D, Riveiro-Falkenbach E, Pennacchi PC, Contreras-Alcalde M, Ibarz N, Cifdaloz M, Catena X, Calvo TG, Cañón E, Alonso-Curbelo D, Suarez J, Osterloh L, Graña O, Mulero F, Megías D, Cañamero M, Martínez-Torrecuadrada JL, Mondal C, Di Martino J, Lora D, Martinez-Corral I, Bravo-Cordero JJ, Muñoz J, Puig S, Ortiz-Romero P, Rodriguez-Peralto JL, Ortega S, Soengas MS.
Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine.
Nature. 2017 Jun 28;546(7660):676-680. doi: 10.1038/nature22977. PubMed PMID: 28658220.
- Esteban-Martínez L, Sierra-Filardi E, McGreal RS, Salazar-Roa M, Mariño G, Seco E, Durand S, Enot D, Graña O, Malumbres M, Cvekl A, Cuervo AM, Kroemer G, Boya P.
Programmed mitophagy is essential for the glycolytic switch during cell differentiation.
EMBO J. 2017 Jun 14;36(12):1688-1706. doi: 10.15252/embj.201695916. PubMed PMID: 28465321
- Tummala KS, Brandt M, Teijeiro A, Graña O, Schwabe RF, Perna C, Djouder N.
Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells.
Cell Rep. 2017 Apr 18;19(3):584-600. doi: 1016/j.celrep.2017.03.059. PubMed PMID: 28423321
- Bakiri L, Hamacher R, Graña O, Guío-Carrión A, Campos-Olivas R, Martinez L, Dienes HP, Thomsen MK, Hasenfuss SC, Wagner EF.
Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation.
J Exp Med. 2017 May 1;214(5):1387-1409. doi: 10.1084/jem.20160935. PubMed PMID: 28356389
- Mancikova V, Montero-Conde C, Perales-Paton J, Fernandez A, Santacana M, Jodkowska K, Inglada-Pérez L, Castelblanco E, Borrego S, Encinas M, Matias-Guiu X, Fraga M, Robledo M.
Multilayer OMIC Data in Medullary Thyroid Carcinoma Identifies the STAT3 Pathway as a Potential Therapeutic Target in RET(M918T) Tumors.
Clin Cancer Res. 2017 Mar 1;23(5):1334-1345. doi: 10.1158/1078-0432.CCR-16-0947. PubMed PMID: 27620278.
- Wasilewski D, Priego N, Fustero-Torre C, Valiente M.
Reactive Astrocytes in Brain Metastasis.
Front. Oncol. 11 December 2017. doi: 10.3389/fonc.2017.00298. PMID: 29312881
2016
- Lopez-Guadamillas E, Fernandez-Marcos PJ, Pantoja C, Muñoz-Martin M, Martínez D, Gómez-López G, Campos-Olivas R, Valverde AM, Serrano M.
p21(Cip1) plays acritical role in the physiological adaptation to fasting through activation of PPARα.
Sci Rep. 2016 Oct 10;6:34542. PubMed PMID: 27721423
- Koumarianou P, Goméz-López G, Santisteban P.
Pax8 controls thyroid follicular polarity through Cadherin-16.
J Cell Sci. 2016 Oct 25. PubMed PMID: 27780871
- García-Fernández M, Karras P, Checinska A, Cañón E, Calvo GT, Gómez-López G, Cifdaloz M, Colmenar A, Espinosa-Hevia L, Olmeda D, Soengas MS.
Metastatic risk and resistance to BRAF inhibitors in melanoma defined by selective allelic loss of ATG5.
Autophagy. 2016 Oct 2;12(10):1776-1790. PubMed PMID: 27464255
- García-Carpizo V, Sarmentero J, Han B, Graña O, Ruiz-Llorente S, Pisano DG, Serrano M, Brooks HB, Campbell RM, Barrero MJ.
NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation.
Sci Rep. 2016 Sep 8;6:32952. PubMed PMID: 27604143
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Multilayer OMIC data in medullary thyroid carcinoma identifies the STAT3 pathway as a potential therapeutic target in RETM918T tumors.
Clin Cancer Res. 2016 Sep 12. PubMed PMID: 27620278
- Martínez P, Gómez-López G, Pisano DG, Flores JM, Blasco MA.
A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance.
Aging Cell. 2016 Sep 1. PubMed PMID: 27586969
- Montero JJ, López de Silanes I, Graña O, Blasco MA.
Telomeric RNAs are essential to maintain telomeres.
Nat Commun. 2016 Aug 17;7:12534. PubMed PMID: 27531349
- Apellániz-Ruiz M, Tejero H, Inglada-Pérez L, Sánchez-Barroso L, Gutiérrez-Gutiérrez G, Calvo I, Castelo B, Redondo A, García-Donás J, Romero-Laorden N, Sereno M, Merino M, Currás-Freixes M, Montero-Conde C, Mancikova V, Åvall-Lundqvist E, Green H, Al-Shahrour F, Cascon A, Robledo M, Rodriguez-Antona C.
Targeted sequencing reveals low-frequency variants in EPHA genes as markers of paclitaxel-induced peripheral neuropathy.
Clin Cancer Res. 2016 Aug 31. PubMed PMID: 27582484
- García-Donas J, Beuselinck B, Inglada-Pérez L, Graña O, Schöffski P, Wozniak A, Bechter O, Apellániz-Ruiz M, Leandro-García LJ, Esteban E, Castellano DE, González Del Alba A, Climent MA, Hernando S, Arranz JA, Morente M, Pisano DG, Robledo M, Rodriguez-Antona C.
Deep sequencing reveals microRNAs predictive of antiangiogenic drug response.
JCI Insight. 2016 Jul 7;1(10):e86051. PubMed PMID: 27699216
- Navarro P, Bueno MJ, Zagorac I, Mondejar T, Sanchez J, Mourón S, Muñoz J, Gómez-López G, Jimenez-Renard V, Mulero F, Chandel NS, Quintela-Fandino M.
Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics.
Cell Rep. 2016 Jun 21;15(12):2705-18. PubMed PMID: 27292634
- Manso L, Mourón S, Tress M, Gómez-López G, Morente M, Ciruelos E, Rubio-Camarillo M, Rodriguez-Peralto JL, Pujana MA, Pisano DG, Quintela-Fandino M.
Analysis of Paired Primary-Metastatic Hormone-Receptor Positive Breast Tumors (HRPBC) Uncovers Potential Novel Drivers of Hormonal Resistance.
PLoS One. 2016 May 19;11(5):e0155840. PubMed PMID: 27195705
- Puram RV, Kowalczyk MS, de Boer CG, Schneider RK, Miller PG, McConkey M, Tothova Z, Tejero H, Heckl D, Järås M, Chen MC, Li H, Tamayo A, Cowley GS, Rozenblatt-Rosen O, Al-Shahrour F, Regev A, Ebert BL.
Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.
Cell. 2016 Apr 7;165(2):303-16. PubMed PMID: 27058663
- Ferrer-Mayorga G, Gómez-López G, Barbáchano A, Fernández-Barral A, Peña C, Pisano DG, Cantero R, Rojo F, Muñoz A, Larriba MJ.
Vitamin D receptor expression and associated gene signature in tumour stromal fibroblasts predict clinical outcome in colorectal cancer.
Gut. 2016 Apr 6. PubMed PMID: 27053631
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Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation.
Cancer Discov. 2016 Apr;6(4):368-81. PubMed PMID: 26951227
- Uluçkan Ö, Jimenez M, Karbach S, Jeschke A, Graña O, Keller J, Busse B, Croxford AL, Finzel S, Koenders M, van den Berg W, Schinke T, Amling M, Waisman A, Schett G, Wagner EF.
Chronic skin inflammation leads to bone loss by IL-17-mediated inhibition of Wnt signaling in osteoblasts.
Sci Transl Med. 2016 Mar 16;8(330):330ra37. PubMed PMID: 27089206
- Ambrogio C, Gómez-López G, Falcone M, Vidal A, Nadal E, Crosetto N, Blasco RB, Fernández-Marcos PJ, Sánchez-Céspedes M, Ren X, Wang Z, Ding K, Hidalgo M, Serrano M, Villanueva A, Santamaría D, Barbacid M.
Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma.
Nat Med. 2016 Mar;22(3):270-7. PubMed PMID: 26855149