MEK inhibition enhances the response to tyrosine kinase inhibitors in acute myeloid leukemia.
Morales ML, Arenas A, Ortiz-Ruiz A, Leivas A, Rapado I, Rodríguez-García A, Castro N, Zagorac I, Quintela-Fandino M, Gómez-López G, Gallardo M, Ayala R, Linares M, Martínez-López J.
Sci Rep. 2019 Dec 9;9(1):18630. doi: 10.1038/s41598-019-54901-9.
PMID: 31819100
Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation.
Helbling PM, Piñeiro-Yáñez E, Gerosa R, Boettcher S, Al-Shahrour F, Manz MG, Nombela-Arrieta C.
Cell Rep. 2019 Dec 3;29(10):3313-3330.e4. doi: 10.1016/j.celrep.2019.11.004.
PMID: 31801092
The correlation between immune subtypes and consensus molecular subtypes in colorectal cancer identifies novel tumour microenvironment profiles, with prognostic and therapeutic implications.
B. Soldevilla, C. Carretero-Puche, G. Gómez-López, F. Al-Shahrour, MC. Riesco, B. Gil-Calderon, L. Alvarez-Vallina, P. Espinosa-Olarte, G. Gómez-Esteves, B. Rubio-Cuesta, J. Sarmentero, A. La Salvia, R. Garcia-Carbonero.
Eur J Cancer. 2019 Oct 31;123:118-129. doi: 10.1016/j.ejca.2019.09.008.
PMID: 31678770
The use of PanDrugs to prioritize anticancer drug treatments in a case of T-ALL based on individual genomic data.
Fernández-Navarro P, López-Nieva P, Piñeiro-Yañez E, Carreño-Tarragona G, Martinez-López J, Sánchez Pérez R, Aroca Á, Al-Shahrour F, Cobos-Fernández MÁ, Fernández-Piqueras J.
BMC Cancer. 2019 Oct 26;19(1):1005. doi: 10.1186/s12885-019-6209-9.
PMID: 31655559
Role of bulge epidermal stem cells and TSLP signaling in psoriasis.
Nuria Gago‐Lopez, Liliana F Mellor, Diego Megías, Guillermo Martín‐Serrano, Ander Izeta, Francisco Jimenez, Erwin F Wagner.
EMBO Mol Med. 2019, 26 Sep, e10697; doi: 10.15252/emmm.201910697.
PMID: 31556482
In silico drug prescription for targeting cancer patient heterogeneity and prediction of clinical outcome.
Elena Piñeiro-Yáñez, María José Jiménez-Santos, Gonzalo Gómez-López, Fátima Al-Shahrour.
Cancers 2019, 11(9), 1361; doi: 10.3390/cancers11091361.
PMID: 31540260
Oncogenic Rag GTPase signalling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR.
Ortega-Molina A, Deleyto-Seldas N, Carreras J, Sanz A, Lebrero-Fernández C, Menéndez C, Vandenberg A, Fernández-Ruiz B, Marín-Arraiza L, Calle Arregui C, Plata-Gómez A, Caleiras E, de Martino A, Martínez-Martín N, Troulé K, Piñeiro-Yañez E, Nakamura N, Araf S, Victoria G, Okosun J, Fitzgibbon, Efeyan A.
Nat Metab. 2019, Aug, doi: 10.1038/s42255-019-0098-8.
PMID: 31579886
Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo.
Peña-Jimenez D, Fontenete S, Megias D, Fustero-Torre C, Graña-Castro O, Castellana D, Loewe R, Perez-Moreno M.
EMBO J. 2019 Sep 2:e101688. doi: 10.15252/embj.2019101688.
PMID: 31475747
TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2.
Marión RM, Montero JJ, López de Silanes I, Graña-Castro O, Martínez P, Schoeftner S, Palacios-Fábrega JA, Blasco MA.
Elife. 2019 Aug 20; 8 (pii: e44656). doi: 10.7554/eLife.44656.
PMID: 31426913
Hsa-miR-139-5p is a prognostic thyroid cancer marker involved in HNRNPF-mediated alternative splicing.
Montero-Conde C, Graña-Castro O, Martín-Serrano G, Martínez-Montes ÁM, Zarzuela E, Muñoz J, Torres-Perez R, Pita G, Cordero-Barreal A, Leandro-García LJ, Letón R, de Silanes IL, Guadalix S, Pérez-Barrios A, Hawkins F, Guerrero-Álvarez A, Álvarez-Escolá C, Regojo-Zapata R, Calsina B, Remacha L, Roldán-Romero JM, Santos M, Lanillos J, Jordá M, Riesco-Eizaguirre G, Zafon C, González-Neira A, Blasco MA, Al-Shahrour F, Rodríguez-Antona C, Cascón A, Robledo M.
Int J Cancer. 2019 Aug 12; doi: 10.1002/ijc.32622.
PMID: 31403184
Integrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/mTOR axis in metastatic pheochromocytoma/paraganglioma.
Calsina B, Castro-Vega LJ, Torres-Pérez R, Inglada-Pérez L, Currás-Freixes M, Roldán-Romero JM, Mancikova V, Letón R, Remacha L, Santos M, Burnichon N, Lussey-Lepoutre C, Rapizzi E, Graña O, Álvarez-Escolá C, A de Cubas A, Lanillos J, Cordero-Barreal A, Martínez-Montes AM, Bellucci A, Amar L, Luiz Fernandes-Rosa F, Calatayud M, Aller J, Lamas C, Sastre-Marcos J, Canu L, Korpershoek E, Timmers HJ, Lenders JWM, Beuschlein F, Fassnacht-Capeller M, Eisenhofer G, Mannelli M, Al-Shahrour F, Favier J, Rodríguez-Antona C, Cascón A, Montero-Conde C, Gimenez-Roqueplo AP, Robledo M.
Theranostics 2019; 9(17):4946-4958. doi:10.7150/thno.35458.
PMID: 31410193
Specific contributions of Cohesin-SA1 and Cohesin-SA2 to TADs and Polycomb domains in embryonic stem cells.
Cuadrado A, Giménez-Llorente D, Kojic A, Rodríguez-Corsino M, Cuartero Y, Martín-Serrano G, Gómez-López G, Marti-Renom MA, Losada A.
Cell Reports. 2019 Jun 18;27(12):3500-3510.e4. doi: 10.1016/j.celrep.2019.05.078.
PMID: 31216471
vulcanSpot: a tool to prioritize therapeutic vulnerabilities in cancer.
Perales-Patón J, Di Domenico T, Fustero-Torre C, Piñeiro-Yáñez E, Carretero-Puche C, Tejero H, Valencia A, Gómez-López G, Al-Shahrour F.
Bioinformatics. 2019 Jun 7. pii: btz465. doi: 10.1093/bioinformatics/btz465.
PMID: 31173067
Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF.
Blasco MT, Navas C, Martín-Serrano G, Graña-Castro O, Lechuga CG, Martín-Díaz L, Djurec M, Li J, Morales-Cacho L, Esteban-Burgos L, Perales-Patón J, Bousquet-Mur E, Castellano E, Jacob HKC, Cabras L, Musteanu M, Drosten M, Ortega S, Mulero F, Sainz B Jr, Dusetti N, Iovanna J, Sánchez-Bueno F, Hidalgo M, Khiabanian H, Rabadán R, Al-Shahrour F, Guerra C, Barbacid M.
Cancer Cell. 2019 Apr 8. pii: S1535-6108(19)30111-4.
PMID: 30975481
Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment.
Urdinguio RG, Lopez V, Bayón GF, Diaz de la Guardia R, Sierra MI, García-Toraño E, Perez RF, García MG, Carella A, Pruneda PC, Prieto C, Dmitrijeva M, Santamarina P, Belmonte T, Mangas C, Diaconu E, Ferrero C, Tejedor JR, Fernandez-Morera JL, Bravo C, Bueno C, Sanjuan-Pla A, Rodriguez RM, Suarez-Alvarez B, López-Larrea C, Bernal T, Colado E, Balbín M, García-Suarez O, Chiara MD, Sáenz-de-Santa-María I, Rodríguez F, Pando-Sandoval A, Rodrigo L, Santos L, Salas A, Vallejo-Díaz J, C Carrera A, Rico D, Hernández-López I, Vayá A, Ricart JM, Seto E, Sima-Teruel N, Vaquero A, Valledor L, Cañal MJ, Pisano D, Graña-Castro O, Thomas T, Voss AK, Menéndez P, Villar-Garea A, Deutzmann R, Fernandez AF, Fraga MF.
Nucleic Acids Res. 2019 Mar 29.
PMID: 30923829
Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma.
López-Nieva P, Fernández-Navarro P, Graña-Castro O, Andrés-León E, Santos J, Villa-Morales M, Cobos-Fernández MÁ, González-Sánchez L, Malumbres M, Salazar-Roa M, Fernández-Piqueras J.
Sci Rep. 2019 March 26;9:5179.
PMID: 30914738
Clonal dynamics monitoring during clinical evolution in chronic lymphocytic leukaemia.
Vázquez-Domínguez I, González-Sánchez L, López-Nieva P, Fernández-Navarro P, Villa-Morales M, Cobos-Fernández MÁ, Sastre I, F Fraga M, F Fernández A, Malumbres M, Salazar-Roa M, Graña-Castro O, Santos J, Llamas P, López-Lorenzo JL, Fernández-Piqueras J.
Oncogene. 2019 Feb 11; doi:10.1038/s41388-019-0746-1.
PMID: 30742097
Clonal dynamics monitoring during clinical evolution in chronic lymphocytic leukaemia.
González-Rincón, J., Gómez, S., Martinez, N., Troulé, K., Perales-Patón, J., Derdak, S., Beltrán, S., Fernández-Cuevas, B., Pérez-Sanz, N., Nova-Gurumeta, S., Gut, I., Al-Shahrour, F., Piris, M.A., García-Marco, J.A., Sánchez-Beato, M.
Sci Rep. 2019 Jan 30;9(1):975.
PMID: 30700761
p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.
Panagiotis Karras, Erica Riveiro-Falkenbach, Estela Cañón, Cristina Tejedo, Tonantzin G. Calvo, Raúl Martínez-Herranz, Direna Alonso-Curbelo, Metehan Cifdaloz, Eva Perez-Guijarro, Gonzalo Gómez-López, Pilar Ximenez-Embun, Javier Muñoz, Diego Megias, David Olmeda, Jorge Moscat, Pablo L. Ortiz-Romero, Jose L. Rodríguez-Peralto, María S. Soengas.
Cancer Cell 2019. Volume 35, 2019-01, 1 – 18.
PMID: 30581152
GENCODE reference annotation for the human and mouse genomes.
Frankish A, Diekhans M, Ferreira AM, Johnson R, Jungreis I, Loveland J, Mudge JM, Sisu C, Wright J, Armstrong J, Barnes I, Berry A, Bignell A, Carbonell Sala S, Chrast J, Cunningham F, Di Domenico T, Donaldson S, Fiddes IT, García Girón C, Gonzalez JM, Grego T, Hardy M, Hourlier T, Hunt T, Izuogu OG, Lagarde J, Martin FJ, Martínez L, Mohanan S, Muir P, Navarro FCP, Parker A, Pei B, Pozo F, Ruffier M, Schmitt BM, Stapleton E, Suner MM, Sycheva I, Uszczynska-Ratajczak B, Xu J, Yates A, Zerbino D, Zhang Y, Aken B, Choudhary JS, Gerstein M, Guigó R, Hubbard TJP, Kellis M, Paten B, Reymond A, Tress ML, Flicek P.
Nucleic Acids Res. 2019 Jan 8;47(D1):D766-D773.
PMID: 30357393
CXCL5 as regulator of neutrophil function in cutaneous melanoma.
Forsthuber A, Lipp K, Andersen L, Ebersberger S, Graña-Castro O, Ellmeier W, Petzelbauer P, Lichtenberger BM, Loewe R.
J Invest Dermatol. 2019 Jan;139(1):186-194.
PMID: 30009831
