Nanobodies targeting ABCC3 for immunotargeted applications in glioblastoma.
Ruiz-López E, Jovčevska I, González-Gómez R, Tejero H, Al-Shahrour F, Muyldermans S, Schuhmacher AJ.
Sci Rep. 2022 Dec 30;12(1):2258 doi: 10.1038/s41598-022-27161-3.
PMID: 36585418
Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A.
Mouron S, Bueno MJ, Lluch A, Manso L, Calvo I, Cortes J, Garcia-Saenz JA, Gil-Gil M, Martinez-Janez N, Apala JV, Caleiras E, Ximénez-Embún P, Muñoz J, Gonzalez-Cortijo L, Murillo R, Sánchez-Bayona R, Cejalvo JM, Gómez-López G, Fustero-Torre C, Sabroso-Lasa S, Malats N, Martinez M, Moreno A, Megias D, Malumbres M, Colomer R, Quintela-Fandino M.
Nat Commun. 2022 Dec 7;13(1):7529. doi: 10.1038/s41467-022-35065-z.
PMID: 36477027
3D chromatin connectivity underlies replication origin efficiency in mouse embryonic stem cells.
Jodkowska K, Pancaldi V, Rigau M, Almeida R, Fernández-Justel JM, Graña-Castro O, Rodríguez-Acebes S, Rubio-Camarillo M, Carrillo-de Santa Pau E, Pisano D, Al-Shahrour F, Valencia A, Gómez M, Méndez J.
Nucleic Acids Res. 2022 Nov 28;50(21):12149-12165. doi: 10.1093/nar/gkac111
PMID: 36453993
Excess weight and anti-PD-1 immune checkpoint inhibitor’s outcomes in non-small cell lung cancer.
Rogado J, Pozo F, Troulé K, Sánchez-Torres JM, Romero-Laorden N, Mondejar R, Donnay O, Ballesteros A, Pacheco-Barcia V, Aspa J, Al-Shahrour F, Alfranca A, Colomer R.
Clin Transl Oncol. 2022 Nov;24(11):2241-2249. doi: 10.1007/s12094-022-02887-8. Epub 2022 Jul 23.
PMID: 35870091
Genomic and phenotypic characterization of 404 individuals with neurodevelopmental disorders caused by CTNNB1 variants.
Kayumi S, Pérez-Jurado LA, Palomares M, Rangu S, Sheppard SE, Chung WK, Kruer MC, Kharbanda M, Amor DJ, McGillivray G, Cohen JS, García-Miñaúr S, van Eyk CL, Harper K, Jolly LA, Webber DL, Barnett CP, Santos-Simarro F, Pacio-Míguez M, Pozo AD, Bakhtiari S, Deardorff M, Dubbs HA, Izumi K, Grand K, Gray C, Mark PR, Bhoj EJ, Li D, Ortiz-Gonzalez XR, Keena B, Zackai EH, Goldberg EM, Perez de Nanclares G, Pereda A, Llano-Rivas I, Arroyo I, Fernández-Cuesta MÁ, Thauvin-Robinet C, Faivre L, Garde A, Mazel B, Bruel AL, Tress ML, Brilstra E, Fine AS, Crompton KE, Stegmann APA, Sinnema M, Stevens SCJ, Nicolai J, Lesca G, Lion-François L, Haye D, Chatron N, Piton A, Nizon M, Cogne B, Srivastava S, Bassetti J, Muss C, Gripp KW, Procopio RA, Millan F, Morrow MM, Assaf M, Moreno-De-Luca A, Joss S, Hamilton MJ, Bertoli M, Foulds N, McKee S, MacLennan AH, Gecz J, Corbett MA.
Genet Med. 2022 Nov;24(11):2351-2366. doi: 10.1016/j.gim.2022.08.006. Epub 2022 Sep 9.
PMID: 36083290
Bioinformatics roadmap for therapy selection in cancer genomics.
Jiménez-Santos MJ, García-Martín S, Fustero-Torre C, Di Domenico T, Gómez-López G, Al-Shahrour F.
Mol Oncol. 2022 Nov;16(21):3881-3908. doi: 10.1002/1878-0261.13286. Epub 2022 Aug 20.
PMID: 35811332
Origins and evolution of human tandem duplicated exon substitution events.
Martinez-Gomez L, Cerdán-Vélez D, Abascal F, Tress ML.
Genome Biol Evol. 2022 Nov 8:evac162. doi: 10.1093/gbe/evac162. Epub ahead of print.
PMID: 36346145
Folliculin-interacting protein FNIP2 impacts on overweight and obesity through a polymorphism in a conserved 3’ untranslated region
Fernández LP, Deleyto-Seldas N, Colmenarejo G, Sanz A, Wagner S, Plata-Gómez AB, Gómez-Patiño M, Molina S, Espinosa-Salinas I, Aguilar-Aguilar E, Ortega S, Graña-Castro O, Loria-Kohen V, Fernández-Marcos PJ, Efeyan A, Ramírez de Molina A.
Genome Biol. 2022 Oct 31;23(1):230. doi: 10.1186/s13059-022-02798-5
PMID: 36316722
Clinical variant interpretation and biologically relevant reference transcripts.
Pozo F, Rodriguez JM, Vázquez J, Tress ML.
NPJ Genom Med. 2022 Oct 18;7(1):59. doi: 10.1038/s41525-022-00329-6.
PMID: 3625796
Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity.
Barradas M, Plaza A, Colmenarejo G, Lázaro I, Costa-Machado LF, Martín-Hernández R, Micó V, López-Aceituno JL, Herranz J, Pantoja C, Tejero H, Diaz-Ruiz A, Al-Shahrour F, Daimiel L, Loria-Kohen V, Ramirez de Molina A, Efeyan A, Serrano M, Pozo OJ, Sala-Vila A, Fernandez-Marcos PJ.
Nat Commun. 2022 Sep 27;13(1):5677. doi: 10.1038/s41467-022-33352-3.
PMID: 36167809
APPRIS principal isoforms and MANE Select transcripts define reference splice variants.
Pozo F, Rodriguez JM, Martínez Gómez L, Vázquez J, Tress ML.
Bioinformatics. 2022 Sep 16;38(Supplement_2):ii89-ii94. doi: 10.1093/bioinformatics/btac473.
PMID: 36124785
Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs.
Jutzi JS, Marneth AE, Ciboddo M, Guerra-Moreno A, Jiménez-Santos MJ, Kosmidou A, Dressman JW, Liang H, Hamel R, Lozano P, Rumi E, Doench JG, Gotlib J, Krishnan A, Elf S, Al-Shahrour F, Mullally A.
Blood. 2022 Sep 15;140(11):1291-1304. doi: 10.1182/blood.2022015629.
PMID: 35763665
Activation of the integrated stress response is a vulnerability for multidrug-resistant FBXW7-deficient cells.
Sanchez-Burgos L, Navarro-González B, García-Martín S, Sirozh O, Mota-Pino J, Fueyo-Marcos E, Tejero H, Antón ME, Murga M, Al-Shahrour F, Fernandez-Capetillo O.
EMBO Mol Med. 2022 Sep 7;14(9):e15855. doi: 10.15252/emmm.202215855. Epub 2022 Jul 2
PMID: 35861150
Mitochondrial RNA methyltransferase TRMT61B is a new, potential biomarker and therapeutic target for highly aneuploid cancers.
Martín A, Epifano C, Vilaplana-Marti B, Hernández I, Macías RIR, Martínez-Ramírez Á, Cerezo A, Cabezas-Sainz P, Garranzo-Asensio M, Amarilla-Quintana S, Gómez-Domínguez D, Caleiras E, Camps J, Gómez-López G, Gómez de Cedrón M, Ramírez de Molina A, Barderas R, Sánchez L, Velasco-Miguel S, Pérez de Castro I.
Cell Death Differ. 2022 Jul 22. doi: 10.1038/s41418-022-01044-6. Epub ahead of print.
PMID: 35869285
Peripheral Blood Mononuclear Cells Predict Therapeutic Efficacy of Immunotherapy in NSCLC.
Rogado J, Pozo F, Troule K, Sánchez-Torres JM, Romero-Laorden N, Mondejar R, Donnay O, Ballesteros A, Pacheco-Barcia V, Aspa J, Al-Shahrour F, Alfranca A, Colomer R.
Cancers (Basel). 2022 Jun 12;14(12):2898. doi: 10.3390/cancers14122898.
PMID: 35740564
Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism
Monteiro C, Miarka L, Perea-García M, Priego N, García-Gómez P, Álvaro-Espinosa L, de Pablos-Aragoneses A, Yebra N, Retana D, Baena P, Fustero-Torre C, Graña-Castro O, Troulé K, Caleiras E, Tezanos P, Muela P, Cintado E, Trejo JL, Sepúlveda JM, González-León P, Jiménez-Roldán L, Moreno LM, Esteban O, Pérez-Núñez Á, Hernández-Lain A, Mazarico Gallego J, Ferrer I, Suárez R, Garrido-Martín EM, Paz-Ares L, Dalmasso C, Cohen-Jonathan Moyal E, Siegfried A, Hegarty A, Keelan S, Varešlija D, Young LS, Mohme M, Goy Y, Wikman H, Fernández-Alén J, Blasco G, Alcázar L, Cabañuz C, Grivennikov SI, Ianus A, Shemesh N, Faria CC, Lee R, Lorigan P, Le Rhun E, Weller M, Soffietti R, Bertero L, Ricardi U, Bosch-Barrera J, Sais E, Teixidor E, Hernández-Martínez A, Calvo A, Aristu J, Martin SM, Gonzalez A, Adler O, Erez N; RENACER; Valiente M.
Nat Med. 2022 Apr;28(4):752-765. doi: 10.1038/s41591-022-01749-8. Epub 2022 Apr 11.
PMID: 35411077
A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis
Zhu L, Retana D, García-Gómez P, Álvaro-Espinosa L, Priego N, Masmudi-Martín M, Yebra N, Miarka L, Hernández-Encinas E, Blanco-Aparicio C, Martínez S, Sobrino C, Ajenjo N, Artiga MJ, Ortega-Paino E, Torres-Ruiz R, Rodríguez-Perales S; RENACER; Soffietti R, Bertero L, Cassoni P, Weiss T, Muñoz J, Sepúlveda JM, González-León P, Jiménez-Roldán L, Moreno LM, Esteban O, Pérez-Núñez Á, Hernández-Laín A, Toldos O, Ruano Y, Alcázar L, Blasco G, Fernández-Alén J, Caleiras E, Lafarga M, Megías D, Graña-Castro O, Nör C, Taylor MD, Young LS, Varešlija D, Cosgrove N, Couch FJ, Cussó L, Desco M, Mouron S, Quintela-Fandino M, Weller M, Pastor J, Valiente M.
EMBO Mol Med. 2022 Mar 7;14(3):e14552. doi: 10.15252/emmm.202114552. Epub 2022 Feb 17.
PMID: 35174975
An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection.
Sanchez-Burgos L, Gómez-López G, Al-Shahrour F, Fernandez-Capetillo O.
Sci Rep. 2022 Jan 31;12(1):1626. doi: 10.1038/s41598-022-05597-x.
PMID: 35102208
bollito: a flexible pipeline for comprehensive single-cell RNA-seq analyses.
García-Jimeno L, Fustero-Torre C, Jiménez-Santos MJ, Gómez-López G, Di Domenico T, Al-Shahrour F.
Bioinformatics. 2022 Jan 27;38(4):1155-1156. doi: 10.1093/bioinformatics/btab758.
PMID: 34788788
IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice
Kovtonyuk LV, Caiado F, Garcia-Martin S, Manz EM, Helbling P, Takizawa H, Boettcher S, Al-Shahrour F, Nombela-Arrieta C, Slack E, Manz MG.
Blood. 2022 Jan 6;139(1):44-58. doi: 10.1182/blood.2021011570.
PMID: 34525198
Endothelial Cell RNA-Seq Data: Differential Expression and Functional Enrichment Analyses to Study Phenotypic Switching.
Pinel GD, Horder JL, King JR, McIntyre A, Mongan NP, López GG, Benest AV.
Methods Mol Biol. 2022;2441:369-426. doi: 10.1007/978-1-0716-2059-5_29.
PMID: 35099752
